Optical controlling reveals time-dependent roles for adult-born dentate granule cells
نویسندگان
چکیده
منابع مشابه
Time-dependent involvement of adult-born dentate granule cells in behavior.
Adult-born neurons are continuously generated and incorporated into the circuitry of the hippocampus throughout life in mammals. Cumulative evidence supports a physiological role for adult-born neurons, yet it not clear whether this subset of dentate granule cells makes a unique contribution to hippocampal function. Perturbation or ablation of adult hippocampal neurogenesis leads to deficits in...
متن کاملExperience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells.
UNLABELLED Behavioral studies have established a role for adult-born dentate granule cells in discriminating between similar memories. However, it is unclear how these cells mediate memory discrimination. Excitability is enhanced in maturing adult-born neurons, spurring the hypothesis that the activity of these cells "directly" encodes and stores memories. An alternative hypothesis posits that ...
متن کاملHilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells.
Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initia...
متن کاملSemaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells
Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell-autonomous manner. In the adult mouse brain, ...
متن کاملAdult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain.
Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature DGCs display distinctive physiological characteristics while undergoing morphological maturation before final integration into the neural circuits. The survival and activity of the adult-born DGCs can be ...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2012
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.3260